Electrical Nanopulses Might Kill Tumors

Killing cells affected by cancer while leaving healthy ones alone is not a new idea.  But, in "Ultra-fast shocks scramble cells," Nature describes a new approach based on electrical nanopulses. These electric shocks last only a few billionths of a second while reaching during this very short amount of time power levels of terawatts. They also are very intriguing, apparently forcing cancer cells to commit suicide. 

The technique involves blasting cells with nanopulses. These are high-power electrical bolts that last a few billionths of a second. They deliver millions of volts - enough power to light up a city, but each burst lasts much less than the blink of an eye. 

Longer shocks blow a cell apart, but researchers have found that the fleeting nanopulses leave the cell membrane unaffected while mixing up its insides. Now they are working out how to vary the timing and intensity of the shocks to make cells behave in specific ways.

Here are two images showing how ultrashort pulses affect the intracellular structure, leaving the cell membrane intact (Credit: Center for Bioelectrics).
Is this technique ready for human deployment? Not quite yet.

There is plenty to be worked out before the human body is zapped with nanopulses. James Weaver, who studies electrical effects in cells at the Massachusetts Institute of Technology, Boston, says they are at an early stage: "There are maybe ten papers published showing that something dramatic is happening."

One puzzling aspect of this technique is the electric shocks are pushing cells to commit suicide. Scientists are not sure why.

One of the most significant discoveries was that nanopulses make mammalian cells commit suicide, rather than blowing them up. This is a relatively gentle way of killing, because scavenger cells come and swallow the debris. By contrast, long electric shocks explode cells and liberate toxic molecules that cause inflammation and pain.

For this reason, researchers hope to use nanopulses to kill cancer cells while leaving healthy tissue intact. Karl Schoenbach's team at the Center for Bioelectrics in Norfolk, Virginia, has already shown that the pulses can shrink mouse tumours by over 50%, and is working on catheters or non-invasive ways to deliver the shocks to the body.

For more information about their research projects, you can look at this page or check this presentation (PDF format, 19 pages, 1.31 MB).
Source: Helen Pearson, Nature, March 16, 2004

The PAP IMI operating principle and mechanism of action

The PAPIMI device produces pulsed electromagnetic type ELF (Extremely Low Frequency), also known as waves PEMF (Pulsed Electro Magnetic Field). These waves, given their very short duration (40-50 microseconds) do not heat the tissue and are able to cross biological tissue up to 15 to 20 inches deep, thus favoring the stimulation and regeneration because they act directly on the physiology the cell.

The pulse is produced in a Plasma ROOM, located inside a solenoidal probe in concentric coils. The probe consists of a silicone tube containing air is circulated in which an electric current that turns the air into plasma. The way that gets the electromagnetic pulse makes it 100% biocompatible, because it is rich of typical frequencies of the constituent elements of air and the necessities of life, such as oxygen and nitrogen.

Figure 1 Membrane potential

The PAPIMI device is used to reactivate the cell physiology in all pathologies osteo-articular muscle and nerve, and also eliminates the pain.

The pain is usually caused by trauma, injuries and accidents of various kinds that determine tissue degeneration, inflammation and, therefore, pain. The multiplicity of agents damaging the body responds with a unique defense mechanism, inflammation, and repair the injured tissue activates mechanisms more or less specific. At the cellular level, the inflammatory state leads to a lowering of the membrane potential which, in turn, causes a reduction of the normal activity of the cell involved, and a reduction of its metabolism.

Reduces the normal transfer of nutrients from outside, through the specific mechanisms of exchange, which, first of all, the sodium potassium pump, and reduces the elimination of waste substances toxic to the cell. Gradually, the cell becomes depleted of oxygen, is enriched with toxins, and so is less than the production of ATP (adenine triphosphate).

Figure 2 The diagram shows the relationship between the concentration inside the cell Na + ions and the potential trans-membrane associated, since they are related to the health status of the cell. The device Papimi ® increases the TMP (Trans Membrane Potential) and decreases Natremia (concentration of Na-).

All cellular functions depend on the continued availability of energy derived from catabolism of organic molecules during the process of cellular respiration, the energy released is stored in the form of molecules of ATP (adenosine triphosphate). ATP is the energy reserves, readily available for all metabolic functions of the cell.

The electromagnetic field generated by the device PAP IMI device is to act directly at the cellular level, exploiting the natural ability of biological structures interact with electromagnetic fields. It is essentially to create resonances, as is now known, each substance has its own characteristic electromagnetic spectrum, and any substance interacts with electromagnetic waves is so non-specific (for example through the transfer of energy) and specifically (interactions based on the particular resonance frequency range).

Figure 3 The diagram shows the relationship between the concentration of intracellular K + and Na + ions, since they are connected to the trans-membrane potential and health status of the cells. The device Papimi ® pushes the curve from the area in the lower right to upper left area, where he represented the condition of young and healthy cells.

The membrane potential has a close relationship with the state of health of the cells. Under physiological conditions this potential assumes a certain value which, depending on the type of cell is between -70 and -90 mV. This potential must be kept constant because the cell remains in physiology.

So happens that, for certain frequencies, the wave emitted by the device is able to interact, resonating with the electromagnetic field produced by the cell. In addition, the cell membrane, by its very nature, conveys well the electromagnetic field.

The effect of electromagnetic pulse has features that allow you to restore the membrane potential, altered by the pathological state. Moreover, precisely due to its composition, the wave penetrates into the cell by stimulating mitochondrial activity, cellular respiration and ATP production.

Therefore, at the cellular level, it has a dual effect: stimulation of bio-electric nature, because it restores the normal membrane potential was altered by the disease, and stimulation of natural bio-chemistry, because the impulse is able to penetrate inside the cell, which is to restore the physiology.

http://papimiuk.blogspot.com

http://papimi.com

UNDISPUTABLE SCIENTIFIC EVIDENCE ABOUT THE NON CHEMICALLY ENERGIZED PAPIMI WATER   click here to see relevant pictures

NEW BREAKTHROUGH FACTS:
The scientific objectiveness of the energized PAPIMI water can be shown by MRI Magnetic Resonance Imaging.   MRI is the most advanced diagnostic imaging technique in medicine, used widely today.
With the following experiment:
Seven identical sealed bottles with the same distilled water are prepared, the 2 of the 7 bottles are exposed 20 minutes with the PAPIMI probe. Then, the same thing is repeated with the other 2 bottles, but exposure time now is 10 minutes. 3 bottle are left without any exposure.
Then all 7 bottles, about six hours later, are brought to an  MRI Center, placed simultaneously and one next to the other in the MRI chamber to be photographed.

Results:

All 3 Bottles without exposure at all comes out        dark
All 2 Bottles exposed 20 minutes comes out             bright
All 2 Bottle exposed 10 minutes comes out           half bright
         

THE SECRETS OF PAPIMI WATER


IN ALL CASES
DRINK AS MUCH AS YOU CAN PAPIMI ENERGIZED WATER
energize your body with papimi energized water and feel the power

NEW PAPPAS' SCIENTIFIC BREAKTHROUGH  PROOF FOR NON CHEMICAL PROPERTIES OF WATER:

"SOME WATER PROPERTIES ARE NOT DETERMINED BY ITS CHEMICAL COMPOSITION BUT ALSO DEPEND ON ITS PREVIOUS MAGNETIC TREATMENT THAT DOES NOT ALTER ITS CHEMICAL COMPOSITION"
THE HYPOTHESIS OF CRYSTAL WATER http://www.theresedilor.com/esther.html by Dr. Esther Del Rio.
Liquid water can form icosahedral water clusters : http://www.lsbu.ac.uk/water/abstrct.html
Water effects on health : References  www.papimi.gr/nero.htm

TREATING WATER WITH PAPIMI
There seems to be two ways of transferring the benefits of papimi.
The first way is to apply the probe over the object one wants to transfer the benefit.
The second way is to treat the water that will be watering the plants.  http://www.papimi.gr/plantpic.htm

See among the numerous experiments, the substantial difference in growth with and without papimi activated water. The PAPIMI activated water.  was given to the pot with white label with beans seeds   After 9 days six seeds have developed considerably.  Normal water.   was given to the next pot with the same number of beans seeds  After 9 days one seed is just underdeveloped.   This experiment was repeated by us very very many times and the Agricultural University of Athens (AUA) with hundreds of plants and always with the same results. See confirming letter of AUA below.  clicktoenlarge         clcktoenlarge     COMPARISON RESULTS : Exposed Plants with twin Plants Non Exposed for about 10 minutes exposures every other day.    http://www.papimi.gr/plantpic.htm   Also, see the typical difference between the plant (peas) growth given activated water (white label on the pot), and the similar plant given normal water, after 14 days

By treating water in shielded plastic bottles as shown, at then to apply or supply the water, if possible, to the object. Hundreds of experiments like this at our Laboratories as well at the Agricultural University of Athens, has shown that something is indeed stored in the water that provides similar or better results as in the first way, by drinking the treated water, by watering plants, etc.

PAPIMI treated water seems to act as the so called crystal water. Analysis and comparisons of the PAPIMI WATER and CRYSTAL WATER http://www.theresedilor.com/esther.html by Dr. Esther Del Rio is on the way and we shall reports the results here as soon as they are conclusive.
What is certain now and here is not all the properties of the water are due to its chemical composition. More beneficial properties seem to be due perhaps to a so called crystalline structure of the water of 37 molecules, which primarily affect biological shaping of plants and animals.

FOR EXAMPLE
 
PAPIMI WATER watering plants develops these plants to their maximum height  from seeds several times faster.
PAPIMI WATER seem to enable the eliminations of scars due to wounds, burns, or even marks due to tumor as direct PAPIMI EXPOSURE seem to do.

Professor
Panos Pappas,
PhD Physics.

 TREATING AND ENERGIZING
WATER WITH PAPIMI

USING PAPIMI AND PAPIMI WATER
SYNERGETICALLY TO ELIMINATE FOOT MARKS
 

Important Notice: A plastic container, a ground and an insulated chair are required as shown, for safety to act independently of the safety leakage controls of papimi device (0.3ma new devices, 3ma older devices). Otherwise and better, you may use papimi device first and then papimi water, or the other way around, afterwards and separately.
IN ALL CASES
DRINK AS MUCH AS YOU CAN PAPIMI ENERGIZED WATER
AND FEEL THE POWER

Treatments for PEMF Devices

Delayed- and Non-Union Fractures

In 1974 it was demonstrated that a pulsed magnetic field applied across the site of a bone fracture can accelerate the healing process (BASSETT et al., 1974). The mechanism of osteogenesis is not clear, however the use of PEMF therapy as an adjuvant therapy for delayed- and non-union fractures was supported by empirical evidence collected through clinical studies. Whilst PEMF therapy may offer some benefit in the treatment of fractures, the evidence is inconclusive and is insufficient to inform current clinical practice.
PEMF therapy has been suggested to enhance healing of fractures that occur in patients with diseases such as diabetes, vascular insufficiency, and osteoporosis, and those taking medications such as steroids and non-steroidal anti-inflammatory drugs. The exact mechanism for fracture healing is unclear; however, it is thought that PEMF therapy causes biochemical changes at the cellular level to accelerate bone formation.

Post-Operative Pain and Edema

There are few clinical trials that have demonstrated PEMF therapy as an effective treatment for tissue trauma, particularly in the early stages of inflammation. Electrical stimulation has been shown to significantly increase the probability of bony arthrodesis in spinal fusions. The use of low-energy, time-varying magnetic fields (commonly referred to as pulsed electromagnetic fields or PEMF) has been successful when used adjunctively to fresh fusions and in the case of treating a failed fusion, PEMF bone growth stimulation is a successful method which avoids a revision surger 

PEMF may be a novel, safe and effective therapeutic tool for use in at least certain subsets of patients with chronic, nonmalignant pain.

For more info on PEMF Devices please visit http://papimiuk.blogspot.com

History of Pulsed Magnetic Field Therapy (PEMF)

History of  Pulsed Magnetic Field Therapy (PEMF)

The use of pulsed magnetic field therapy (PEMF) in clinical applications dates back over 500 years. In the 15th century, Swiss physician and alchemist Paracelsus used lodestones, or naturally magnetized pieces of the mineral magnetite, to treat conditions such as epilepsy, diarrhea, and hemorrhage. He believed that the ability of magnets to attract iron could be replicated by attracting disease away from the body. In the late 18th century, the Austrian physician Franz Anton Mesmer, who originated the idea of "animal magnetism", described the healing properties of passing magnets over the open veins of patients.

In the mid-19th century, magnetic ointments produced in New York were introduced as remedies for a whole spectrum of illnesses such as headaches, inflammation of the bowels, burns, fever sores, rheumatism, gout, and toothache.

Although electricity’s potential to aid bone healing was reported as early as 1841, it was not until the mid-1950s that scientists seriously studied the subject. Fukada’s and Yasuda’s discovery of the electric potential of bone provides evidence of electricity’s effect in promoting osteogenesis (bone growth), particularly in long bone non-unions.During the 1970s, Bassett and his team introduced a new approach for the treatment of delayed fractures, a technique that employed a very specific biphasic low frequency signal  to be applied for non-union/delayed fractures.

The use of electrical stimulation in the lumbosacral region was first attempted by Alan Dwyer of Australia. In 1974, he reported successful initiation of graft incorporation in 11 of 12 fusion patients. Since that time, electrical stimulation has been shown to significantly increase the probability of bony arthrodesis in spinal fusions.

In 1979 the FDA approved non-invasive devices using pulsed electromagnetic fields designed to stimulate bone growth.In 1991, PEMF Therapy was approved in the US for adjunctive use in the palliative treatment of postoperative pain and edema in superficial soft tissue.

In 2004, pulsed electromagnetic field system was approved by FDA as an adjunct to cervical fusion surgery in patients at high risk for non-fusion.

The use of PEMF stimulation has been found to be safe.It has also been proven safe and effective in treatment of delayed union in long bone fractures and patients at a risk of non-union following spinal fusion surgeries.


Source http://en.wikipedia.org/wiki/PEMF

For more info on PEMF Therapy and Magnetic Field Therapy visit: www.papimiuk.blogpost.com

Physiological effects of using Papimi Device

PHYSIOLOGICAL EFFECTS

• The analgesia achieved by the release of the endorphin of enkephalin, which acts as an inhibitor of pain.
• The regulation of membrane permeability to ions Na and K. When the cell membrane is disrupted, the electromagnetic and electric fields polarize the cells and provide them the energy they need to re-establish the electrostatic balance, by restoring the sodium-potassium pump to its normal levels. In this way, the magnetic fields help in the reduction of inflammation and edema and as a result the cell functions normally again.
• The regulation of glucide, lipid and protein metabolism, which are the effect of the beneficial influence of the sympathetic and the parasympathetic system.
• The balance of hormone secretion.
• The strengthening of the immune system by increasing the number of leukocytesτων,platelets and gamma globulin.
• The increase of collagen, due to the reduction of the adenylic acid (AMP).
• The reduction of osteoclasts.
• The increase of calcification, osteoblasts and prostaglandin.
• The improvement of blood flow and oxygen absorption(oxygenation).
• Binding free radicals.
• Positive results in the restoration of traumatic situations of the muscles and chronic locomotor system disorders.
• Anti-inflammatory effect.
• The increase of metabolism and biological activity of he cells.

     So far, no adverse effect by the application of Magnetic Fields has been reported and the results are only positive. Finally, the fact that magnetotherapy does not cause temperature raise of the exposed tissues must be underlined.